Hemoglobin SO-Arab and α-thalassemia diagnosed in an adult: A case-based review of the hemoglobinopathies

Am J Med Sci. 2013 Oct;346(4):325-7. doi: 10.1097/MAJ.0b013e318275625b.

Abstract

Hemoglobin SO-Arab is a rare sickling disorder with a clinical course similar to that of hemoglobin SS. Hemoglobin C-Harlem is another rare condition that produces sickling disorders in affected individuals with a disease course and electrophoretic findings similar to that of hemoglobin SO-Arab. The authors report the case of a 38-year-old African American man with hemoglobin SO-Arab and the challenges that may arise in working up a rare hemoglobinopathy.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Anemia, Sickle Cell / diagnosis*
  • Anemia, Sickle Cell / genetics
  • Anemia, Sickle Cell / metabolism
  • Black or African American
  • Chromatography, High Pressure Liquid / methods
  • Electrophoresis / methods
  • Genetic Techniques
  • Hemoglobin, Sickle* / analysis
  • Hemoglobins, Abnormal* / analysis
  • Heterozygote
  • Humans
  • Louisiana
  • Male
  • alpha-Thalassemia / diagnosis*
  • alpha-Thalassemia / genetics
  • alpha-Thalassemia / metabolism

Substances

  • Hemoglobin, Sickle
  • Hemoglobins, Abnormal
  • hemoglobin Arab