A case of corneal endotheliitis with mumps virus RNA in aqueous humor detected by rt-PCR

Ocul Immunol Inflamm. 2013 Apr;21(2):150-2. doi: 10.3109/09273948.2012.747619. Epub 2012 Dec 19.

Abstract

Purpose: To report a case of corneal endotheliitis following the mumps parotitis.

Methods: A 46-year-old man noticed ciliary infection and visual loss in the right eye after mumps parotitis. To determine the cause of the disease, reverse transcription-polymerase chain reaction (RT-PCR) was used to amplify mumps virus RNA in samples from the aqueous humor.

Results: RT-PCR revealed mumps virus RNA in an aqueous humor sample. Although full recovery of vision was achieved within 1 month of the onset, corneal endothelial cells were severely damaged.

Conclusions: The authors have detected mumps virus in the aqueous humor by RT-PCR for the first time.

Publication types

  • Case Reports

MeSH terms

  • Aqueous Humor / virology
  • Diagnosis, Differential
  • Endothelium, Corneal / pathology
  • Endothelium, Corneal / virology*
  • Eye Infections, Viral / diagnosis
  • Eye Infections, Viral / virology*
  • Humans
  • Keratitis / diagnosis
  • Keratitis / virology*
  • Male
  • Middle Aged
  • Mumps / diagnosis
  • Mumps / virology*
  • Mumps virus / genetics*
  • RNA, Viral / analysis*
  • Reverse Transcriptase Polymerase Chain Reaction / methods*

Substances

  • RNA, Viral