Complex karyotypic anomalies, including an i(5p) marker chromosome, in malignant mixed mesodermal tumor of the ovary

Cancer Genet Cytogenet. 1990 May;46(1):65-9. doi: 10.1016/0165-4608(90)90009-y.

Abstract

Cytogenetic analysis of short-term cultures initiated from an ovarian malignant mixed mesodermal tumor yielded the following karyotype: 59-61, XX,t(1;?)(p36;?), +t(1;9) (q43;q21), +t(2;?)(p25;?), +i(5p), +i(5p), +7, +t(7;?)(p13;?), +8,der(11) (pter----cen----q23::q13----q23::q13----q23::?), +12, + der(13)t(13;15)(q21;q15), -15,der(16) (16qter----cen----16p13::hsr::8q21----8qter), +19, + der(20)t(X;20)(q13;p13), -22, +4 - 6mar. Because the only other cytogenetically characterized ovarian neoplasm of this rare histopathologic subtype also had a small metacentric marker interpreted as an isochromosome for the short arm of a B-group chromosome, we suggest that i(5p) constitutes a nonrandom anomaly in mixed mesodermal tumors.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / genetics
  • Adenocarcinoma / pathology
  • Aged
  • Cell Differentiation
  • Chromosome Aberrations*
  • Chromosome Disorders*
  • Female
  • Genetic Markers
  • Humans
  • Karyotyping
  • Mesoderm
  • Ovarian Neoplasms / genetics*
  • Ovarian Neoplasms / pathology
  • Sarcoma / genetics
  • Sarcoma / pathology

Substances

  • Genetic Markers