The incidence of non-fatal infections after staging laparotomy in 95 adult patients with Hodgkin's disease was compared with that of 94 non-splenectomized patients. In addition, mortality of infections in 248 splenectomized patients was compared with mortality in 275 non-splenectomized patients. The observation time was 10 years from start of therapy. No difference was found between splenectomized and non-splenectomized adult Hodgkin's patients as to frequency and death from infection. However, the incidence of more serious infections was significantly higher in advanced disease (stage III and IV) as compared with localized disease (stage I and II). Deaths from rapid fatal infection occurred only in patients with advanced disease, unrespective of splenectomy.