Cerebrospinal fluid (1,3)-β-D-glucan detection as an aid for diagnosis of iatrogenic fungal meningitis

J Clin Microbiol. 2013 Apr;51(4):1285-7. doi: 10.1128/JCM.00061-13. Epub 2013 Jan 30.

Abstract

This case series highlights our experience with use of the Fungitell assay for quantifying (1,3)-β-d-glucan in cerebrospinal fluid during the current U.S. outbreak of fungal meningitis related to contaminated methylprednisolone acetate. This test may prove a useful adjunct in diagnosis and management of exposed patients.

Publication types

  • Case Reports
  • Evaluation Study
  • Research Support, N.I.H., Extramural

MeSH terms

  • Adult
  • Aged
  • Cerebrospinal Fluid / chemistry*
  • Drug Contamination
  • Female
  • Humans
  • Iatrogenic Disease*
  • Male
  • Meningitis, Fungal / diagnosis*
  • Methylprednisolone / administration & dosage
  • Methylprednisolone / adverse effects
  • Methylprednisolone / analogs & derivatives
  • Methylprednisolone Acetate
  • Middle Aged
  • Proteoglycans
  • beta-Glucans / cerebrospinal fluid*

Substances

  • Proteoglycans
  • beta-Glucans
  • polysaccharide-K
  • Methylprednisolone Acetate
  • Methylprednisolone