Abstract
Objective:
To clarify the correlation between serum fetuin-A levels and the presence and severity of coronary artery disease (CAD) in patients with type 2 diabetes (T2DM).
Methods:
A total of 241 consecutive patients with T2DM and 69 controls were recruited. Serum fetuin-A levels were analyzed by enzyme-linked immunosorbent assay. The presence and severity of CAD were evaluated by coronary angiography (CAG).
Results:
Serum fetuin-A levels are independently correlated with the presence and severity of CAD in T2DM patients.
Conclusions:
Fetuin-A might serve as a potential biomarker for reflecting the development and progression of CAD in T2DM patients.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Aged
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Biomarkers / blood
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Blood Pressure
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Body Mass Index
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Case-Control Studies
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Coronary Artery Disease / blood*
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Coronary Artery Disease / complications
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Coronary Artery Disease / diagnostic imaging
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Coronary Artery Disease / pathology
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Coronary Vessels / diagnostic imaging
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Coronary Vessels / metabolism*
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Coronary Vessels / pathology
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Diabetes Mellitus, Type 2 / blood*
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Diabetes Mellitus, Type 2 / complications
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Diabetes Mellitus, Type 2 / diagnostic imaging
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Diabetes Mellitus, Type 2 / pathology
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Female
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Humans
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Lipoproteins, LDL / blood
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Male
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Middle Aged
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Radiography
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Severity of Illness Index
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Triglycerides / blood
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alpha-2-HS-Glycoprotein / analysis
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alpha-2-HS-Glycoprotein / metabolism*
Substances
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AHSG protein, human
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Biomarkers
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Lipoproteins, LDL
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Triglycerides
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alpha-2-HS-Glycoprotein