Association of aryl hydrocarbon receptor gene polymorphism with the neurobehavioral function and autonomic nervous system function changes induced by benzo[a]pyrene exposure in coke oven workers

J Occup Environ Med. 2013 Mar;55(3):265-71. doi: 10.1097/JOM.0b013e318278272f.

Abstract

Objective: To analyze the association of aryl hydrocarbon receptor (AhR) gene polymorphism and the neurotoxicity induced by benzo[a]pyrene (B[a]P) in coke oven workers.

Methods: Subjects, 214 coke oven workers and 81 controls, were detected for neurobehavioral function and autonomic nervous system (ANS) function. Airborne B[a]P concentration, urinary 1-hydroxypyrene level, and AhR gene polymorphisms were determined and analyzed for their association with B[a]P neurotoxicity.

Results: Neurobehavioral function and ANS function were significantly decreased and dependent on B[a]P dose. The AhR GG, GA, and AA genotypes in G1661A fitted the Hardy-Weinberg equation, whereas C1549T and G1708A gene mutants were not detected. Indices indicating neurotoxicity showed no significant difference among individuals with AA, GG, or GA genotype except for the confusion-bewilderment (P > 0.05).

Conclusion: The AhR gene polymorphism is not thought to correlate with B[a]P neurotoxicity among coke oven workers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Air Pollutants, Occupational / adverse effects*
  • Air Pollutants, Occupational / analysis
  • Autonomic Nervous System Diseases / chemically induced
  • Autonomic Nervous System Diseases / diagnosis
  • Autonomic Nervous System Diseases / genetics
  • Autonomic Nervous System Diseases / urine
  • Basic Helix-Loop-Helix Transcription Factors / genetics*
  • Benzo(a)pyrene / adverse effects*
  • Benzo(a)pyrene / analysis
  • Biomarkers / urine
  • Case-Control Studies
  • China
  • Coke*
  • Extraction and Processing Industry
  • Genetic Markers
  • Genotyping Techniques
  • Humans
  • Male
  • Middle Aged
  • Nervous System Diseases / chemically induced
  • Nervous System Diseases / diagnosis
  • Nervous System Diseases / genetics*
  • Nervous System Diseases / urine
  • Neuropsychological Tests
  • Neurotoxicity Syndromes / diagnosis
  • Neurotoxicity Syndromes / etiology
  • Neurotoxicity Syndromes / genetics
  • Neurotoxicity Syndromes / urine
  • Occupational Diseases / chemically induced
  • Occupational Diseases / diagnosis
  • Occupational Diseases / genetics*
  • Occupational Diseases / urine
  • Occupational Exposure / adverse effects*
  • Occupational Exposure / analysis
  • Polymorphism, Single Nucleotide
  • Pyrenes / urine
  • Receptors, Aryl Hydrocarbon / genetics*
  • Surveys and Questionnaires

Substances

  • AHR protein, human
  • Air Pollutants, Occupational
  • Basic Helix-Loop-Helix Transcription Factors
  • Biomarkers
  • Coke
  • Genetic Markers
  • Pyrenes
  • Receptors, Aryl Hydrocarbon
  • Benzo(a)pyrene
  • 1-hydroxypyrene