APOA5 genotype influences the association between 25-hydroxyvitamin D and high density lipoprotein cholesterol

Atherosclerosis. 2013 May;228(1):188-92. doi: 10.1016/j.atherosclerosis.2013.02.006. Epub 2013 Feb 13.

Abstract

Objective: Circulating levels of 25-hydroxyvitamin D (25OHD) are positively associated with high density lipoprotein (HDL) cholesterol. We sought to replicate a previously reported interaction between APOA5 genotype and vitamin D, and to examine whether HDL-associated genetic loci modify the association between serum 25OHD and HDL cholesterol.

Methods: We examined whether 42 single nucleotide polymorphisms (SNPs) modify the association between serum 25OHD and HDL cholesterol in the 1958 British Birth cohort (aged 45 years, n = 4978).

Results: We identified a borderline interaction between the SNP rs12272004 (near the APOA5) and serum 25OHD on HDL cholesterol (P(interaction) = 0.05). The interaction was particularly prominent among the samples collected during winter (P(interaction) = 0.001). None of the other loci showed an interaction with serum 25OHD concentrations on HDL cholesterol.

Conclusions: Our study in 4978 British Whites provides further support that APOA5 genotype modifies the association between vitamin D metabolites and HDL cholesterol.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apolipoprotein A-V
  • Apolipoproteins A / genetics*
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / genetics*
  • Cholesterol, HDL / blood*
  • Cohort Studies
  • Environment
  • Female
  • Genotype
  • Humans
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide / genetics
  • Seasons
  • United Kingdom
  • Vitamin D / analogs & derivatives*
  • Vitamin D / blood
  • White People / genetics*

Substances

  • APOA5 protein, human
  • Apolipoprotein A-V
  • Apolipoproteins A
  • Cholesterol, HDL
  • Vitamin D
  • 25-hydroxyvitamin D