Newborn body fat: associations with maternal metabolic state and placental size

Camilla M Friis; Elisabeth Qvigstad; Marie Cecilie Paasche Roland; Kristin Godang; Nanna Voldner; Jens Bollerslev; Tore Henriksen

doi:10.1371/journal.pone.0057467

Newborn body fat: associations with maternal metabolic state and placental size

PLoS One. 2013;8(2):e57467. doi: 10.1371/journal.pone.0057467. Epub 2013 Feb 27.

Authors

Camilla M Friis¹, Elisabeth Qvigstad, Marie Cecilie Paasche Roland, Kristin Godang, Nanna Voldner, Jens Bollerslev, Tore Henriksen

Affiliation

¹ Section for Obstetrics, Women and Children's Division, Rikshospitalet, Oslo University Hospital, Oslo, Norway. camilla.friis@ous-hf.no

Abstract

Background: Neonatal body composition has implications for the health of the newborn both in short and long term perspective. The objective of the current study was first to explore the association between maternal BMI and metabolic parameters associated with BMI and neonatal percentage body fat and to determine to which extent any associations were modified if adjusting for placental weight. Secondly, we examined the relations between maternal metabolic parameters associated with BMI and placental weight.

Methods: The present work was performed in a subcohort (n = 207) of the STORK study, an observational, prospective study on the determinants of fetal growth and birthweight in healthy pregnancies at Oslo University Hospital, Norway. Fasting glucose, insulin, triglycerides, free fatty acids, HDL- and total cholesterol were measured at week 30-32. Newborn body composition was determined by Dual-Energy X-Ray Absorptiometry (DXA). Placenta was weighed at birth. Linear regression models were used with newborn fat percentage and placental weight as main outcomes.

Results: Maternal BMI, fasting glucose and gestational age were independently associated with neonatal fat percentage. However, if placental weight was introduced as a covariate, only placental weight and gestational age remained significant. In the univariate model, the determinants of placenta weight included BMI, insulin, triglycerides, total- and HDL-cholesterol (negatively), gestational weight gain and parity. In the multivariable model, BMI, total cholesterol HDL-cholesterol, gestational weight gain and parity remained independent covariates.

Conclusion: Maternal BMI and fasting glucose were independently associated with newborn percentage fat. This effect disappeared by introducing placental weight as a covariate. Several metabolic factors associated with maternal BMI were associated with placental weight, but not with neonatal body fat. Our findings are consistent with a concept that the effects of maternal BMI and a number of BMI-related metabolic factors on fetal fat accretion to a significant extent act by modifying placental weight.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adipose Tissue / physiology*
Adult
Birth Weight / physiology
Body Mass Index
Demography
Female
Humans
Infant, Newborn
Metabolism*
Mothers*
Organ Size
Placenta / anatomy & histology*
Pregnancy

Grants and funding

The project has been financially supported by South-Eastern Norway Regional Health Authority, The National Resource Centre for Women's Health, Division of Obstetrics and Gynaecology, Oslo University Hospital, Rikshospitalet; The Department of Obstetrics, Women and Children's Division, Oslo University Hospital, Rikshospitalet, Oslo, Norway; The Faculty of Medicine, Thematic Research Area, University of Oslo. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.