Genetic drift of equine 2 influenza A virus (H3N8), 1963-1988: analysis by oligonucleotide mapping

Vet Microbiol. 1990 Apr;22(2-3):225-36. doi: 10.1016/0378-1135(90)90109-9.

Abstract

Comparative analysis by RNA oligonucleotide fingerprints of total genomic RNA as well as the individual RNA segments of equine 2 influenza A virus strains from 1963, 1968, 1979, 1984, 1987 and 1988 revealed genetic diversity. Strains from the epizootic outbreak during 1978-1979 showed minor differences among their genomes. The Swedish isolates from 1979 up to 1988 showed increasing genomic heterogeneity indicating genetic drift.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral / analysis
  • Cross Reactions
  • Gene Frequency*
  • Hemagglutination Inhibition Tests
  • Influenza A Virus, H3N8 Subtype*
  • Influenza A virus / genetics*
  • Influenza A virus / immunology
  • Nucleotide Mapping
  • Oligonucleotides / analysis*
  • RNA, Viral / analysis*
  • Sequence Homology, Nucleic Acid

Substances

  • Antibodies, Viral
  • Oligonucleotides
  • RNA, Viral