Physicians are often asked questions related to cancer frequency in their communities, particularly in Louisiana because of the perception of high cancer rates in this region. When individuals perceive a higher than normal rate of cancer in their geographic area, time frame, or group of people, questions about the potential role of environmental contamination are often raised. The purpose of this article is to educate clinicians about the concept of cancer clusters so they can further disseminate this knowledge to patients concerned about increased cancer frequency in their communities. This article will accomplish this goal through the consideration of potential questions or concerns patients might present related to cancer frequency in their communities.