1. An eight-arm radial maze was the experimental model used to investigate spatial learning in rats of different ages and in old rats treated with Acetyl-L-Carnitine. 2. Extramaze visual cues were minimized in order to study the rat's ability to perform using a strategy. 3. The experimental findings indicated a deterioration of the old rat's ability to learn and solve the radial maze. 4. Long-term treatment (8 months) with Acetyl-L-Carnitine was found to antagonize such a deterioration.