Similarities between familial and sporadic autopsy-proven progressive supranuclear palsy

Neurology. 2013 May 28;80(22):2076-8. doi: 10.1212/WNL.0b013e318294b2eb. Epub 2013 May 1.

Abstract

Progressive supranuclear palsy (PSP) is a relatively common neurodegenerative tauopathy clinically characterized by parkinsonism, axial rigidity, and supranuclear gaze palsy. Pathologic findings of PSP are neuronal loss, gliosis, and neurofibrillary tangles in basal ganglia, diencephalon, and brainstem; there is increasing recognition of clinicopathologic variants of PSP.(1.)

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Diagnosis, Differential
  • Genetic Predisposition to Disease*
  • Genome-Wide Association Study
  • Humans
  • Risk
  • Severity of Illness Index
  • Supranuclear Palsy, Progressive / diagnosis*
  • Supranuclear Palsy, Progressive / genetics
  • Supranuclear Palsy, Progressive / pathology