Mutational analysis of SKP2 and P27 in Chinese Han women with premature ovarian failure

Zhiyi Zhao; Deying Wei; Yulan Mu; Yingying Qin; Guangyu Li; Linlin Cui; Zi-Jiang Chen

doi:10.1016/j.rbmo.2013.03.017

Mutational analysis of SKP2 and P27 in Chinese Han women with premature ovarian failure

Reprod Biomed Online. 2013 Jul;27(1):104-6. doi: 10.1016/j.rbmo.2013.03.017. Epub 2013 Apr 13.

Authors

Zhiyi Zhao¹, Deying Wei, Yulan Mu, Yingying Qin, Guangyu Li, Linlin Cui, Zi-Jiang Chen

Affiliation

¹ Center for Reproductive Medicine, Provincial Hospital Affiliated to Shandong University, 324 Jingwu Road, Jinan 250021, China.

PMID: 23665265
DOI: 10.1016/j.rbmo.2013.03.017

Abstract

P27 and SKP2, a major regulator of P27, play a crucial role in ovarian function in mice. Both P27-deficient and SKP2-deficient female mice develop premature ovarian failure (POF). The coding regions of SKP2 and P27 were examined in 200 Chinese women with POF and 200 control volunteers. This study is the first to investigate SKP2 in POF. No plausible pathogenic mutations were detected. The results suggest that mutations in SKP2 and P27 are not common in Chinese Han women with POF.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Asian People / genetics
Cyclin-Dependent Kinase Inhibitor p27 / genetics*
DNA Mutational Analysis
Female
Humans
Polymorphism, Single Nucleotide
Primary Ovarian Insufficiency / genetics*
S-Phase Kinase-Associated Proteins / genetics*

Substances

S-Phase Kinase-Associated Proteins
Cyclin-Dependent Kinase Inhibitor p27