Customized growth curves for identification of large-for-gestational age neonates in pre-eclamptic women

Abstract

Objectives: To compare the role of two nomograms to classify large-for-gestational age (LGA) neonates in women with pre-eclampsia and to determine the frequency of placental vascular lesions according to the timing of delivery.

Method: This cohort study included 118 consecutive women with pre-eclampsia delivering between 23 and 41 weeks’ gestation. The frequencies of LGA neonates according to customized growth curves and a national birth weight (BW) chart were compared. Similarly, the frequencies of LGA neonates and histological placental vascular lesions were compared between pre-eclamptic women delivering at <34 weeks (n=40) and those delivering later (n=78).

Results: Customized growth curves allowed classification of a higher proportion of LGA neonates than did BW curves (18.6% (22/118) vs 10.2% (12/118); P=0.002). Among pre-eclamptic women delivering at ≥34 weeks, but not earlier, the proportion of neonates classified as LGA by customized growth curves was higher than that classified by BW curves (26.9% (21/78) vs 15.4% (12/78); P=0.004). Placental vascular lesions were less frequent in pre-eclamptic women delivering at ≥34 weeks than in those delivering earlier (41% (32/78) vs 62.5% (25/40); P=0.03).

Conclusions: Customized growth curves allow classification of a higher proportion of LGA neonates than do population birth weight curves among women with pre-eclampsia delivering at ≥34 weeks. Pre-eclamptic women delivering at ≥34 weeks have fewer placental vascular lesions than do those delivering earlier.