The genetic variant on chromosome 10p14 is associated with risk of colorectal cancer: results from a case-control study and a meta-analysis

Qin Qin; Li Liu; Rong Zhong; Li Zou; Jieyun Yin; Beibei Zhu; Beibei Cao; Wei Chen; Jigui Chen; Xiaorong Li; Tingting Li; Xuzai Lu; Jiao Lou; Juntao Ke; Sheng Wei; Xiaoping Miao; Shaofa Nie

doi:10.1371/journal.pone.0064310

The genetic variant on chromosome 10p14 is associated with risk of colorectal cancer: results from a case-control study and a meta-analysis

PLoS One. 2013 May 22;8(5):e64310. doi: 10.1371/journal.pone.0064310. Print 2013.

Authors

Qin Qin¹, Li Liu, Rong Zhong, Li Zou, Jieyun Yin, Beibei Zhu, Beibei Cao, Wei Chen, Jigui Chen, Xiaorong Li, Tingting Li, Xuzai Lu, Jiao Lou, Juntao Ke, Sheng Wei, Xiaoping Miao, Shaofa Nie

Affiliation

¹ Department of Epidemiology and Biostatistics, and the Ministry of Education Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China.

Abstract

Background: A common single nucleotide polymorphism (SNP), rs10795668, located at 10p14, was first identified to be significantly associated with risk of colorectal cancer (CRC) by a genome-wide association study (GWAS) in 2008; however, another GWAS and following replication studies yielded conflicting results.

Methods: We conducted a case-control study of 470 cases and 475 controls in a Chinese population and then performed a meta-analysis, integrating the current study and 9 publications to evaluate the association between rs10795668 and CRC risk. Heterogeneity among studies and publication bias were assessed by the χ²-based Q statistic test and Egger's test, respectively.

Results: In the case-control study, significant association between the SNP and CRC risk was observed, with per-A-allele OR of 0.71 (95%CI: 0.54-0.94, P = 0.017). The following meta-analysis further confirmed the significant association, with per-A-allele OR of 0.91 (95%CI: 0.89-0.93, P(heterogeneity) >0.05) in European population and 0.86 (95%CI: 0.78-0.96, P(heterogeneity) <0.05) in Asian population. Besides, sensitivity analyses and publication bias assessment indicated the robust stability and reliability of the results.

Conclusions: Results from our case-control study and the followed meta-analysis confirmed the significant association of rs10795668 with CRC risk.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Aged
Case-Control Studies
China
Chromosomes, Human, Pair 10*
Colorectal Neoplasms / genetics*
Female
Genetic Heterogeneity
Genetic Predisposition to Disease*
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide*

Grants and funding

This work was supported by the National Natural Science Foundation of China (NSFC-81172752, and NSFC-81222038) and the Talent introduction plan of Huazhong University of Science and Technology (Li Liu). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.