Side chain and backbone structure-dependent subcellular localization and toxicity of conjugated polymer nanoparticles

Chem Commun (Camb). 2013 Jul 11;49(54):6048-50. doi: 10.1039/c3cc43015d.

Abstract

The subcellular localization and toxicity of conjugated polymer nanoparticles (CPNs) are dependent on the chemical structure of the side chains and backbone. Primary amine-containing CPNs exhibit high Golgi localization with no toxicity. Incorporation of short ethylene oxide and tertiary amine side chains contributes to decreased Golgi localization and increased toxicity, respectively.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Amines / chemistry
  • Cell Survival / drug effects
  • Ethylene Oxide / chemistry
  • Golgi Apparatus / metabolism
  • HeLa Cells
  • Humans
  • Nanoparticles / chemistry*
  • Nanoparticles / toxicity
  • Polymers / chemistry*

Substances

  • Amines
  • Polymers
  • Ethylene Oxide