Cerebrospinal fluid HIV-1 compartmentalization in a patient with AIDS and acute varicella-zoster virus meningomyeloradiculitis

E Liana Falcone; Ademiposi A Adegbulugbe; Virginia Sheikh; Hiromi Imamichi; Robin L Dewar; Dima A Hammoud; Irini Sereti; H Clifford Lane

doi:10.1093/cid/cit356

Cerebrospinal fluid HIV-1 compartmentalization in a patient with AIDS and acute varicella-zoster virus meningomyeloradiculitis

Clin Infect Dis. 2013 Sep;57(5):e135-42. doi: 10.1093/cid/cit356. Epub 2013 May 31.

Authors

E Liana Falcone¹, Ademiposi A Adegbulugbe, Virginia Sheikh, Hiromi Imamichi, Robin L Dewar, Dima A Hammoud, Irini Sereti, H Clifford Lane

Affiliation

¹ Laboratory of Clinical Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892-1684, USA. emilia.falcone@nih.gov

Abstract

We report a case of AIDS presenting as varicella-zoster virus (VZV) meningomyeloradiculitis associated with human immunodeficiency virus (HIV) quasispecies compartmentalization within the cerebrospinal fluid (CSF), and a CSF viral load that was 1 log higher than in peripheral blood. Prolonged antiviral therapy for both VZV and HIV type 1 was associated with partial resolution.

Keywords: central nervous system compartmentalization; human immunodeficiency virus; meningomyeloradiculitis; varicella-zoster virus; viral quasispecies.

Publication types

Case Reports
Research Support, N.I.H., Extramural

MeSH terms

Acquired Immunodeficiency Syndrome / complications*
Acquired Immunodeficiency Syndrome / drug therapy
Acquired Immunodeficiency Syndrome / virology
Antiviral Agents / therapeutic use
Cerebrospinal Fluid / virology*
HIV-1 / isolation & purification*
Herpes Zoster / complications*
Herpes Zoster / virology
Humans
Male
Meningitis, Viral / pathology*
Middle Aged
Myelitis / pathology*
Radiculopathy / pathology*

Substances

Antiviral Agents