Equine developmental orthopaedic diseases--a genome-wide association study of first phalanx plantar osteochondral fragments in Standardbred trotters

Anim Genet. 2013 Dec;44(6):766-9. doi: 10.1111/age.12064. Epub 2013 Jun 7.

Abstract

Palmar/plantar osteochondral fragments (POF) in fetlock joints commonly affect and influence the athletic performance of horses. In this study, we used the Equine SNP50 BeadChip® to perform a genome-wide association study of metatarsophalangeal POF in 176 Norwegian Standardbred trotter yearlings. Putative quantitative trait loci (QTL) for medial and/or lateral POF, and medial POF only were identified on ECA1, 2, 7, 9 and 31, whereas for lateral POF, only on ECA7, 11, 27 and X. The moderate number of QTL evidences a complex inheritance and suggests various genes controlling POF development in medial and lateral locations.

Keywords: Equine SNP50 BeadChip®; horse; osteochondrosis; palmar/plantar osteochondral fragments; quantitative trait loci.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Genome-Wide Association Study / veterinary
  • Horse Diseases / diagnostic imaging*
  • Horse Diseases / genetics*
  • Horses
  • Joint Diseases / diagnostic imaging
  • Joint Diseases / genetics
  • Joint Diseases / veterinary*
  • Logistic Models
  • Norway
  • Oligonucleotide Array Sequence Analysis / veterinary
  • Polymorphism, Single Nucleotide / genetics*
  • Radiography