Abstract
BMI1 is a known oncogenic transcriptional repressor in glioblastoma stem-like cells, but its downstream mediators are poorly understood. Recently, in Cancer Cell, Gargiulo et al. (2013) designed a rational in vivo RNAi screen based on BMI1 ChIP-seq from neural progenitors and identified functional tumor suppressor targets, including Atf3 and Cbx7.
Copyright © 2013 Elsevier Inc. All rights reserved.
MeSH terms
-
Animals
-
Bone Morphogenetic Proteins / metabolism*
-
Endoplasmic Reticulum Stress*
-
Glioblastoma / genetics*
-
Humans
-
Neoplastic Stem Cells / metabolism*
-
Polycomb Repressive Complex 1 / genetics*
-
Polycomb Repressive Complex 1 / metabolism*
-
Proto-Oncogene Proteins / metabolism*
-
Transforming Growth Factor beta / metabolism*
Substances
-
Bone Morphogenetic Proteins
-
Proto-Oncogene Proteins
-
Transforming Growth Factor beta
-
Polycomb Repressive Complex 1