Association study of BDNF with completed suicide in the Japanese population

Psychiatry Res. 2013 Oct 30;209(3):734-6. doi: 10.1016/j.psychres.2013.05.030. Epub 2013 Jul 11.

Abstract

We explored the association between the brain-derived neurotrophic factor gene with suicide using 307 Japanese completed suicides, 380 healthy controls, and data from previously published samples. The meta-analyses of the valine with methionine in codon 66 (Val66Met) single nucleotide polymorphism (SNP) showed that the Met-allele tended to be associated with attempted suicide in Asian populations, but not with the completed suicide.

Keywords: Association study; Brain-derived neurotrophic factor; Suicide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Brain-Derived Neurotrophic Factor / genetics*
  • Female
  • Gene Frequency
  • Genetic Association Studies
  • Genotype
  • Humans
  • Japan / epidemiology
  • Male
  • Meta-Analysis as Topic
  • Methionine / genetics
  • Polymorphism, Single Nucleotide / genetics*
  • Self-Injurious Behavior / epidemiology
  • Self-Injurious Behavior / genetics*
  • Suicide*
  • Valine / genetics

Substances

  • Brain-Derived Neurotrophic Factor
  • Methionine
  • Valine