Short, terminally modified 2'-OMe RNAs as inhibitors of microRNA

Chem Commun (Camb). 2013 Aug 28;49(67):7397-9. doi: 10.1039/c3cc43174f.

Abstract

We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Base Sequence
  • Down-Regulation / drug effects
  • HeLa Cells
  • Humans
  • MicroRNAs / antagonists & inhibitors*
  • MicroRNAs / chemistry
  • Oligonucleotides / chemistry*
  • Oligonucleotides / pharmacology*
  • Stilbenes / chemistry*
  • Stilbenes / pharmacology*

Substances

  • MicroRNAs
  • Oligonucleotides
  • Stilbenes