Abstract
We applied 14-mer 2'-OMe RNAs as inhibitors of selected micro RNAs. To improve their properties, we introduced a trimethoxystilbene residue at the 5'-terminus and three 2'-fluoro-2'-deoxynucleotides at the 3'-terminus to obtain potent inhibitors, whose mismatch discrimination is substantially better than that of typically applied >18-mers.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Down-Regulation / drug effects
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HeLa Cells
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Humans
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MicroRNAs / antagonists & inhibitors*
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MicroRNAs / chemistry
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Oligonucleotides / chemistry*
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Oligonucleotides / pharmacology*
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Stilbenes / chemistry*
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Stilbenes / pharmacology*
Substances
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MicroRNAs
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Oligonucleotides
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Stilbenes