Abstract
Endothelial dysfunction plays a key role in the development and progression of cardiovascular disease. In patients with hypertension, endothelial dysfunction is characterized by a decrease of vasodilator factors release. Recent evidence highlights the involvement of regulatory T cell in the cardiovascular physiology and pathology. An increasing body of data suggest that an imbalance in the immune system triggers inflammation and compromises the cardiovascular homeostasis. In this mini-review, we will highlight the role of immune regulatory T cells in hypertension-induced vascular dysfunction.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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Atherosclerosis / complications
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Atherosclerosis / immunology
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Blood Pressure
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CD4-Positive T-Lymphocytes / immunology*
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Endothelium, Vascular / pathology
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Forkhead Transcription Factors / metabolism*
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Homeostasis
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Humans
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Hypertension / complications
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Hypertension / immunology*
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Immune Tolerance
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Inflammation
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Interleukin-2 Receptor alpha Subunit / metabolism*
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Mice
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Microcirculation
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T-Lymphocytes, Regulatory / immunology*
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Vascular Diseases / immunology*
Substances
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FOXP3 protein, human
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Forkhead Transcription Factors
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Interleukin-2 Receptor alpha Subunit