STIM-ORAI interactions that control the CRAC channel

Curr Top Membr. 2013:71:33-58. doi: 10.1016/B978-0-12-407870-3.00002-0.

Abstract

The Ca(2+) sensor STIM1 and the Ca(2+) channel ORAI1 are the fundamental working machinery of the CRAC channel, a classical pathway for store-operated Ca(2+) entry. This chapter focuses on the protein-protein interactions of STIM and ORAI proteins that control the channel.

Keywords: CRAC channel; CRAC current; ORAI1; ORAI3; STIM1; calcium; gating; interaction; mutation; protein; store-operated calcium entry; structure.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Calcium Channels / chemistry
  • Calcium Channels / genetics
  • Calcium Channels / metabolism*
  • Calcium-Binding Proteins / metabolism
  • Calmodulin / metabolism
  • Conserved Sequence
  • Humans
  • Membrane Proteins / chemistry
  • Membrane Proteins / metabolism*
  • Models, Molecular
  • Molecular Sequence Data
  • Mutation, Missense
  • Neoplasm Proteins / chemistry
  • Neoplasm Proteins / metabolism*
  • ORAI1 Protein
  • Protein Binding
  • Protein Interaction Domains and Motifs
  • Protein Structure, Secondary
  • Severe Combined Immunodeficiency / genetics
  • Stromal Interaction Molecule 1

Substances

  • CRACR2A protein, human
  • Calcium Channels
  • Calcium-Binding Proteins
  • Calmodulin
  • Membrane Proteins
  • Neoplasm Proteins
  • ORAI1 Protein
  • ORAI1 protein, human
  • STIM1 protein, human
  • Stromal Interaction Molecule 1