Abstract
The Ca(2+) sensor STIM1 and the Ca(2+) channel ORAI1 are the fundamental working machinery of the CRAC channel, a classical pathway for store-operated Ca(2+) entry. This chapter focuses on the protein-protein interactions of STIM and ORAI proteins that control the channel.
Keywords:
CRAC channel; CRAC current; ORAI1; ORAI3; STIM1; calcium; gating; interaction; mutation; protein; store-operated calcium entry; structure.
Copyright © 2013 Elsevier Inc. All rights reserved.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Review
MeSH terms
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Amino Acid Sequence
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Calcium Channels / chemistry
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Calcium Channels / genetics
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Calcium Channels / metabolism*
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Calcium-Binding Proteins / metabolism
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Calmodulin / metabolism
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Conserved Sequence
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Humans
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Membrane Proteins / chemistry
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Membrane Proteins / metabolism*
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Models, Molecular
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Molecular Sequence Data
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Mutation, Missense
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Neoplasm Proteins / chemistry
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Neoplasm Proteins / metabolism*
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ORAI1 Protein
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Protein Binding
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Protein Interaction Domains and Motifs
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Protein Structure, Secondary
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Severe Combined Immunodeficiency / genetics
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Stromal Interaction Molecule 1
Substances
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CRACR2A protein, human
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Calcium Channels
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Calcium-Binding Proteins
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Calmodulin
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Membrane Proteins
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Neoplasm Proteins
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ORAI1 Protein
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ORAI1 protein, human
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STIM1 protein, human
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Stromal Interaction Molecule 1