The concentration of bisphenol A in urine is affected by specimen collection, a preservative, and handling

M P Longnecker; K Harbak; G E Kissling; J A Hoppin; M Eggesbo; T A Jusko; J Eide; H M Koch

doi:10.1016/j.envres.2013.07.002

The concentration of bisphenol A in urine is affected by specimen collection, a preservative, and handling

Environ Res. 2013 Oct:126:211-4. doi: 10.1016/j.envres.2013.07.002. Epub 2013 Jul 27.

Authors

M P Longnecker¹, K Harbak, G E Kissling, J A Hoppin, M Eggesbo, T A Jusko, J Eide, H M Koch

Affiliation

¹ Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NIH/DHHS/USA, PO Box 12233, MD A3-05, NC 27709, USA. Electronic address: Longnec1@niehs.nih.gov.

Abstract

In urine specimens that were collected from pregnant women in a large cohort, 24% contained more than 10 ng/ml of total bisphenol A (BPA), suggesting external contamination. Therefore, we conducted an investigation of the source(s) of extraneous BPA in the specimens. We found that under the conditions used to collect urine specimens in the epidemiologic study, contamination with BPA occurred, and by two separate mechanisms.

Keywords: BPA; Bisphenol A; Contamination; LOD; LOQ; MoBa; Norwegian Mother and Child Cohort Study; QC; SD; Urine specimen collection; bisphenol A; limit of detection; limit of quantitation; quality control; standard deviation.

Published by Elsevier Inc.

Publication types

Research Support, N.I.H., Intramural

MeSH terms

Adult
Benzhydryl Compounds / urine*
Female
Humans
Phenols / urine*
Pregnancy
Specimen Handling*

Substances

Benzhydryl Compounds
Phenols
bisphenol A

Abstract

Publication types

MeSH terms

Substances

Grants and funding