Development of multi-walled carbon nanotubes reinforced monetite bionanocomposite cements for orthopedic applications

Mater Sci Eng C Mater Biol Appl. 2013 Oct;33(7):4323-30. doi: 10.1016/j.msec.2013.06.029. Epub 2013 Jun 28.

Abstract

In this study, we present results of our research on biodegradable monetite (DCPA, CaHPO4) cement with surface-modified multi-walled carbon nanotubes (mMWCNTs) as potential bone defect repair material. The cement pastes showed desirable handling properties and possessed a suitable setting time for use in surgical setting. The incorporation of mMWCNTs shortened the setting time of DCPA and increased the compressive strength of DCPA cement from 11.09±1.85 MPa to 21.56±2.47 MPa. The cytocompatibility of the materials was investigated in vitro using the preosteoblast cell line MC3T3-E1. An increase of cell numbers was observed on both DCPA and DCPA-mMWCNTs. Scanning electron microscopy (SEM) results also revealed an obvious cell growth on the surface of the cements. Based on these results, DCPA-mMWCNTs composite cements can be considered as potential bone defect repair materials.

Keywords: Bone cement; Monetite; Multi-walled carbon nanotube.

Publication types

  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Animals
  • Biocompatible Materials / pharmacology*
  • Bone Cements / pharmacology*
  • Calcium Phosphates / pharmacology*
  • Cell Count
  • Cell Line
  • Compressive Strength / drug effects
  • Durapatite / chemistry
  • Elastic Modulus / drug effects
  • Mice
  • Nanocomposites / chemistry*
  • Nanocomposites / ultrastructure
  • Nanotubes, Carbon / chemistry*
  • Nanotubes, Carbon / ultrastructure
  • Orthopedics*
  • Spectroscopy, Fourier Transform Infrared
  • Time Factors
  • X-Ray Diffraction

Substances

  • Biocompatible Materials
  • Bone Cements
  • Calcium Phosphates
  • Nanotubes, Carbon
  • Durapatite
  • calcium phosphate, dibasic, anhydrous