The prognostic value of SOX2 expression in non-small cell lung cancer: a meta-analysis

Yansu Chen; Yefei Huang; Yulin Huang; Junjie Chen; Shouyu Wang; Jianwei Zhou

doi:10.1371/journal.pone.0071140

The prognostic value of SOX2 expression in non-small cell lung cancer: a meta-analysis

PLoS One. 2013 Aug 19;8(8):e71140. doi: 10.1371/journal.pone.0071140. eCollection 2013.

Authors

Yansu Chen¹, Yefei Huang, Yulin Huang, Junjie Chen, Shouyu Wang, Jianwei Zhou

Affiliation

¹ Department of Molecular Cell Biology and Toxicology, Jiangsu Key Lab of Cancer Biomarkers, Prevention & Treatment, Cancer Center; School of Public Health, Nanjing Medical University, Nanjing, Jiangsu Province, People's Republic of China.

Abstract

Objective: To investigate the association of SOX2 expression in tumor with clinicopathological features and survival of non-small-cell lung carcinoma (NSCLC) patients.

Methods: Publications assessing the clinicopathological characteristics and prognostic significance of SOX2 in NSCLC were identified up to May 2013. A meta-analysis of eligible studies was performed using standard statistical methods to clarify the association between SOX2 expression and these clinical parameters.

Results: A total of eight studies met the inclusion criteria. Analysis of these data showed that SOX2 expression was positively associated with squamous histology, (pooled OR = 5.26, 95% CI: 1.08-25.6, P = 0.040). Simultaneously, we also found that SOX2 expression was positively associated with overall survival (pooled HR = 0.65, 95% CI: 0.47-0.89, P = 0.007, random-effect).

Conclusions: SOX2 expression in tumor is a candidate positive prognostic biomarker for NSCLC patients.

Publication types

Meta-Analysis
Research Support, Non-U.S. Gov't

MeSH terms

Biomarkers, Tumor / metabolism
Carcinoma, Non-Small-Cell Lung / diagnosis*
Carcinoma, Non-Small-Cell Lung / metabolism*
Carcinoma, Non-Small-Cell Lung / mortality
Gene Expression Regulation, Neoplastic*
Humans
Lung Neoplasms / diagnosis*
Lung Neoplasms / metabolism*
Lung Neoplasms / mortality
Prognosis
SOXB1 Transcription Factors / metabolism*
Sensitivity and Specificity

Substances

Biomarkers, Tumor
SOX2 protein, human
SOXB1 Transcription Factors

Grants and funding

Research supported by the National Natural Science Foundation of China (#30930080, #81161120537, and #81001231), the Natural Science Foundation of Jiangsu Province (#BK2012840), the Postdoctoral Science Foundation of China (#20100481165), Undergraduates Practice and Innovation Training Project of Jiangsu Higher Education Institutes (#2012JSSPITP1021), and the Priority Academic Program Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.