Mechanistic comparison between gastric bypass vs. duodenal switch with sleeve gastrectomy in rat models

PLoS One. 2013 Sep 9;8(9):e72896. doi: 10.1371/journal.pone.0072896. eCollection 2013.

Abstract

Background: Both gastric bypass (GB) and duodenal switch with sleeve gastrectomy (DS) have been widely used as bariatric surgeries, and DS appears to be superior to GB. The aim of this study was to better understand the mechanisms leading to body weight loss by comparing these two procedures in experimental models of rats.

Methods: Animals were subjected to GB, DS or laparotomy (controls), and monitored by an open-circuit indirect calorimeter composed of comprehensive laboratory animal monitoring system and adiabatic bomb calorimeter.

Results: Body weight loss was greater after DS than GB. Food intake was reduced after DS but not GB. Energy expenditure was increased after either GB or DS. Fecal energy content was increased after DS but not GB.

Conclusion: GB induced body weight loss by increasing energy expenditure, whereas DS induced greater body weight loss by reducing food intake, increasing energy expenditure and causing malabsorption in rat models.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bariatric Surgery
  • Body Weight
  • Cytokines / blood
  • Disease Models, Animal
  • Duodenum / surgery*
  • Energy Metabolism
  • Feeding Behavior
  • Gastrectomy*
  • Gastric Bypass* / mortality
  • Laparotomy
  • Male
  • Postoperative Complications / mortality
  • Rats

Substances

  • Cytokines

Grants and funding

The present research has been supported by funding from the Central Norway Regional Health Authority, and the European Union Seventh Framework Programme (FP7/2007–2013) under grant agreement n 266408. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.