A strategy for addressing aspirin hypersensitivity in patients requiring urgent PCI

Eur Heart J Acute Cardiovasc Care. 2012 Apr;1(1):75-8. doi: 10.1177/2048872612441580.

Abstract

Aspirin is key to the treatment of acute myocardial infarction, particularly if stent implantation is considered. In patients with a history of hypersensitivity to aspirin, the optimal management of ST-segment elevation acute myocardial infarction is unclear. We suggest a strategy for addressing this problem by performing percutaneous coronary intervention with antiplatelet therapy by intravenous glycoprotein IIb/IIIa receptor blockers and performing rapid oral desensitization in the ensuing hours, once the patient has stabilized.

Keywords: Acute myocardial infarction; allergy; aspirin; desensitisation.