Abstract
Diversity-oriented biosynthesis of a library of antimycin-like compounds (380 altogether) was accomplished by using multiplex combinatorial biosynthesis. The core strategy depends on the use of combinatorial chemistry at different biosynthetic stages. This approach is applicable for the diversification of polyketides, nonribosomal peptides, and the hybrids that share a similar biosynthetic logic.
Keywords:
antimycins; biosynthesis; combinatorial chemistry; dilactones; natural products.
Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Alkylation
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Animals
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Antimycin A / analogs & derivatives*
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Antimycin A / biosynthesis
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Antimycin A / pharmacology
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Antimycin A / toxicity
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Candida albicans / drug effects
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Catalysis
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Cell Line
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Cell Survival / drug effects
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Combinatorial Chemistry Techniques*
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Copper / chemistry
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Genetic Variation*
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Lactones / chemistry
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Mice
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Peptides / chemistry
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Peptides / metabolism
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Polyketides / metabolism
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Small Molecule Libraries / chemistry
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Small Molecule Libraries / metabolism
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Small Molecule Libraries / toxicity
Substances
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Lactones
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Peptides
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Polyketides
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Small Molecule Libraries
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antimycin
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Antimycin A
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Copper