Relationship between platelet volume indices with macrovascular and peripheral neuropathy complications in type 2 diabetic patients

Abstract

Background: The relationship of platelet volume indices including mean platelet volume (MPV) and platelet distribution width (PDW) with carotid intima-media thickness (IMT) as well as vibration perception threshold (VPT) was investigated in type 2 diabetic patients.

Methods: A total of 500 type 2 diabetic patients (298 male, 202 female) were enrolled. Clinical and laboratory data were collected from hospital records.

Results: Both MPV and PDW were significantly associated with carotid IMT, after adjustment for confounding factors including age, systolic blood pressure, total cholesterol and creatinine (0.833 ± 0.029 mm vs. 0.955 ± 0.030 mm; 0.839 ± 0.029 mm vs. 0.955 ± 0.030 mm; P = 0.0015 and P = 0.022, respectively). Agreed with carotid IMT analysis results, significant association was found between PDW and VPT as tertiles (15.760 ± 1.091V vs 20.187 ± 1.094V, P = 0.016). In multivariable analysis, both MPV and PDW were significantly associated with VPT (P = 0.021 and P = 0.007, respectively). However, only PDW, but not MPV, was significantly associated with carotid IMT (P = 0.002).

Conclusions: These findings implied the predictive value of platelets volume indices in vascular and peripheral neuropathy complications in type 2 diabetes.

Keywords: intima-media thickness; mean platelet volume; platelet distribution width; type 2 diabetes; vibration perception threshold; 颈动脉内中膜增厚，平均血小板体积，血小板分布宽度，2型糖尿病，震动感觉阈值.