Effect of neonatal monosodium glutamate on the activities of glutamate dehydrogenase and aminotransferases in the circumventricular organs of rat brain

M Bawari; G Nagesh Babu; M M Ali; U K Misra

doi:10.1007/BF00806557

Effect of neonatal monosodium glutamate on the activities of glutamate dehydrogenase and aminotransferases in the circumventricular organs of rat brain

Amino Acids. 1995 Dec;8(4):393-5. doi: 10.1007/BF00806557.

Authors

M Bawari¹, G Nagesh Babu, M M Ali, U K Misra

Affiliation

¹ Department of Neurology, SGPG Institute of Medical Sciences, P.O. Box 375, 226014, Lucknow, UP, India.

PMID: 24186517
DOI: 10.1007/BF00806557

Abstract

Glutamate (Glu) the major amino acid in mammalian brain and most dietary proteins possesses neurotransmitter as well as neurotoxic properties. We administered monosodium glutamate (MSG) 4 mg/g bwt, sc on postnatal day (PND) 1 through 10 to rats on alternate days or daily and sacrificed them on PND 45 or PND 90 respectively. The activities of glutamate dehydrogenase and aminotransferases were evaluated in the circumventricular organs of brain. Results show that neonatal MSG produces alterations in glutamate metabolism in blood-brain-barrier deficient regions.