A functional variant rs1820453 in YAP1 and breast cancer risk in Chinese population

PLoS One. 2013 Nov 1;8(11):e79056. doi: 10.1371/journal.pone.0079056. eCollection 2013.

Abstract

Background: To investigate the association between rs1820453 which located in the promoter region of yes-associated protein 1 (YAP1) gene and breast cancer (BC) risk.

Method and findings: We conducted a hospital-based case-control study including a total of 480 BC cases and 545 cancer-free controls in Chinese population. Then the expression quantitative trait locus (e-QTL) analysis was performed to explore the possible function of rs1820453 to the YAP1 gene expression. The association between rs1820453 and BC risk was significantly identified with the odds ratio (OR) was 1.27 (95 % confidence interval (CI) =1.03-1.57) under allelic model when adjusted by age and menopausal status. In addition, the correlation analysis of rs1820453 and YAP1 expression level found that this variant was significantly associated with the gene expression in Chinese population. When compared with level of mRNA expression of the AA genotype (6.011 ± 0.046), the mRNA expression level in CC genotype (5.903 ± 0.026) was statistically lower (P=0.024).

Conclusion: The results from this study suggested that rs1820453 A>C change may affect the gene expression and contribute to the risk of developing BC in Chinese population though larger sample-size studies along with functional experiments were anticipated to warrant the results.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adaptor Proteins, Signal Transducing / genetics*
  • Adult
  • Asian People / genetics
  • Breast Neoplasms / ethnology
  • Breast Neoplasms / genetics*
  • Case-Control Studies
  • China
  • Female
  • Gene Expression Regulation, Neoplastic
  • Gene Frequency
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Middle Aged
  • Odds Ratio
  • Phosphoproteins / genetics*
  • Polymorphism, Single Nucleotide*
  • Risk Factors
  • Transcription Factors
  • YAP-Signaling Proteins

Substances

  • Adaptor Proteins, Signal Transducing
  • Phosphoproteins
  • Transcription Factors
  • YAP-Signaling Proteins
  • YAP1 protein, human

Grants and funding

This work was supported by the National Natural Science Foundation of China (grants 81001171 and 81202094). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.