Inhibition of ethoxyresorufin-O-deethylase (EROD) activity in mixtures of 2,3,7,8-tetrachlorodibenzo-p-dioxin and polychlorinated biphenyls : EROD acitivity as biomarker in TCDD and PCB risk assessment

M Tysklind; A B Bosveld; P Andersson; E Verhallen; T Sinnige; W Seinen; C Rappe; M van den Berg

doi:10.1007/BF02986768

Inhibition of ethoxyresorufin-O-deethylase (EROD) activity in mixtures of 2,3,7,8-tetrachlorodibenzo-p-dioxin and polychlorinated biphenyls : EROD acitivity as biomarker in TCDD and PCB risk assessment

Environ Sci Pollut Res Int. 1995 Jul;2(4):211-6. doi: 10.1007/BF02986768.

Authors

M Tysklind¹, A B Bosveld, P Andersson, E Verhallen, T Sinnige, W Seinen, C Rappe, M van den Berg

Affiliation

¹ Institute of Environmental Chemistry, Umeå University, S-901 87, Umeå, Sweden.

PMID: 24234689
DOI: 10.1007/BF02986768

Abstract

Induction of ethoxyresorufin-O-deethylase (EROD) activity and porphyrin accumulation shows different structure-activity relationships for different polychlorinated biphenyls (PCBs) and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). Interactions between the two responses can strongly influence the induction and activity of EROD. The results support the conclusion that there are nonadditive interactions between nondioxin-like PCBs and dioxin-like compounds. The interaction between EROD activity and the porphyrin biosynthesis makes the prerequisite of additivity in the toxic equivalency factor concept for environmental mixtures highly spurious. Inhibition of EROD activity caused by non-dioxin like compounds could have a significant impact on the value of EROD activity as a biomarker in the present methods of risk assessment for these compounds.