Development of the hematopoietic system and disorders of hematopoiesis that present during infancy and early childhood

Karen S Fernández; Pedro A de Alarcón

doi:10.1016/j.pcl.2013.08.002

Development of the hematopoietic system and disorders of hematopoiesis that present during infancy and early childhood

Pediatr Clin North Am. 2013 Dec;60(6):1273-89. doi: 10.1016/j.pcl.2013.08.002.

Authors

Karen S Fernández¹, Pedro A de Alarcón

Affiliation

¹ Division of Hematology/Oncology, Department of Pediatrics, University of Illinois College of Medicine at Peoria, Children's Hospital of Illinois, 530 Northeast Glen Oak Avenue, Peoria, IL 61637, USA.

PMID: 24237971
DOI: 10.1016/j.pcl.2013.08.002

Abstract

This article reviews the ontogeny of hematopoiesis (embryonic/fetal/newborn phases) and its regulation and provides examples of the disorders of hematopoiesis that present in the newborn or infant and their pathophysiology. Many of these disorders are discussed in depth in other articles of this issue.

Keywords: Early childhood; Hematopoiesis; Hematopoietic system; Infancy.

Publication types

Review

MeSH terms

Cell Differentiation
Child, Preschool
Fetus
Hematopoiesis / physiology*
Hematopoietic Stem Cells / physiology*
Hematopoietic System / physiology*
Humans
Infant