Mild footshock stress dissociates substance P from substance K and dynorphin from Met- and Leu-enkephalin

Brain Res. 1986 Sep 3;381(2):393-6. doi: 10.1016/0006-8993(86)90097-1.

Abstract

Mild footshock stress selectively activates ventral tegmental area dopamine neurons innervating the prefrontal cortex. The same stressor rapidly dissociates ventral tegmental substance P from its preprotachykinin-derived co-transmitter substance K, and preproenkephalin B-derived dynorphin B from preproenkephalin A-derived Met-enkephalin-Arg-Gly-Leu and Leu-enkephalin. Mild footshock stress may provide a paradigm for studying both peptidergic modulation of brain dopaminergic neurons and the dynamic regulation of tachykinin and opioid peptide transcription, processing and utilization.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Brain Chemistry*
  • Enkephalin, Leucine / analysis
  • Enkephalin, Methionine / analysis
  • Frontal Lobe / analysis
  • Male
  • Neurokinin A
  • Neuropeptides / analysis*
  • Rats
  • Rats, Inbred Strains
  • Stress, Psychological / metabolism*
  • Substance P / analysis
  • Tegmentum Mesencephali / analysis

Substances

  • Neuropeptides
  • Substance P
  • Enkephalin, Methionine
  • Enkephalin, Leucine
  • Neurokinin A