Haplotype analysis of the DISC1 Ser704Cys variant in Japanese suicide completers

Psychiatry Res. 2014 Jan 30;215(1):249-51. doi: 10.1016/j.psychres.2013.11.007. Epub 2013 Nov 16.

Abstract

The present study investigated the genetic association of the disrupted-in-schizophrenia 1 (DISC1) gene with suicide using 398 Japanese completed suicides and 511 healthy controls. The functional Ser704Cys variant of DISC1 was nominally associated with completed suicide. Enhanced evidence of association was observed in a multi-marker sliding window haplotype analysis (the lowest p=0.002). These findings warrant further studies with a larger sample size to confirm the association of DISC1 with suicide.

Keywords: Completed suicide; Disrupted-in-schizophrenia 1; Haplotype analysis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Asian People / genetics
  • Female
  • Genetic Association Studies
  • Haplotypes*
  • Humans
  • Japan
  • Male
  • Middle Aged
  • Nerve Tissue Proteins / genetics*
  • Polymorphism, Single Nucleotide*
  • Suicide*

Substances

  • DISC1 protein, human
  • Nerve Tissue Proteins