This article provides an overview of research on mercury (Hg) contamination in Malaysia and its evolution from 1979 to 2012. The objective of this paper was to review and provide an understanding of Hg exposures in the environment, humans, and food in Malaysia. Hg concentration in the environment is high in areas of West Port, Malacca Straits, Prai, and Johor because these areas receive anthropogenic metal loads brought about by industrial activities. Hg concentration in humans is related to seafood intake (dietary), environmental conditions, and different geographical locations. Hg levels in food showed higher concentration in the West coast of Peninsular Malaysia. Hg concentration is also present in the country's tropical fruits, which is related to agrochemical and fertilizer usage. This review showed that there is an urgent need to identify Hg toxicology and bioaccumulation as well as the health effects of Hg exposure in different ecological compartments. This review aims to provide helpful recommendations for future Hg biomonitoring and research in Malaysia.