Activation and retention: a magnetic resonance probe for the detection of acute thrombosis

Angew Chem Int Ed Engl. 2014 Jan 20;53(4):1140-3. doi: 10.1002/anie.201308607. Epub 2013 Dec 11.

Abstract

Blood-clot formation that results in the complete occlusion of a blood vessel (thrombosis) often leads to serious life-threatening events, such as strokes and heart attacks. As the composition of a thrombus changes as it matures, new imaging methods that are capable of distinguishing new clots from old clots may yield important diagnostic and prognostic information. To address this need, an activatable magnetic resonance (MR) probe that is responsive to a key biochemical process associated with recently formed clots has been developed.

Keywords: disulfide bonds; enzymatic activation; fibrin; imaging agents; magnetic resonance imaging.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Acute Disease
  • Contrast Media* / chemistry
  • Contrast Media* / metabolism
  • Gadolinium* / chemistry
  • Gadolinium* / metabolism
  • Humans
  • Magnetic Resonance Imaging*
  • Molecular Conformation
  • Peptides* / chemistry
  • Peptides* / metabolism
  • Protein Disulfide-Isomerases / metabolism
  • Venous Thrombosis / diagnosis*

Substances

  • Contrast Media
  • EP-2104R
  • Peptides
  • Gadolinium
  • Protein Disulfide-Isomerases