RETRACTED: Akt2 knockout alleviates prolonged caloric restriction-induced change in cardiac contractile function through regulation of autophagy

J Mol Cell Cardiol. 2014 Jun:71:81-91. doi: 10.1016/j.yjmcc.2013.12.010. Epub 2013 Dec 22.

Abstract

This article has been retracted: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy). At the request of the University of Wyoming, this article has been retracted. Although an investigation report from Air Force Medical University found no evidence of misconduct, the University of Wyoming’s institutional investigation of the work authored by Dr. Jun Ren found evidence of data irregularities in Figures 2, 3, and 4 that affect the reported results and conclusions. All authors have been notified of the retraction of this article.

Keywords: AMPK; Akt2; Autophagy; Caloric restriction; Myocardial; mTOR.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Retracted Publication

MeSH terms

  • Animals
  • Autophagy / genetics*
  • Autophagy-Related Protein-1 Homolog
  • Calcium / metabolism
  • Caloric Restriction*
  • Heart / physiology*
  • Male
  • Mice
  • Mice, Inbred C57BL
  • Mice, Knockout
  • Myocardial Contraction / physiology*
  • Myocardium / cytology*
  • Myocytes, Cardiac / metabolism
  • Myocytes, Cardiac / physiology
  • Phosphorylation
  • Protein Serine-Threonine Kinases / genetics
  • Protein Serine-Threonine Kinases / metabolism
  • Proto-Oncogene Proteins c-akt / deficiency*
  • Proto-Oncogene Proteins c-akt / genetics*
  • Random Allocation
  • TOR Serine-Threonine Kinases / genetics
  • TOR Serine-Threonine Kinases / metabolism

Substances

  • mTOR protein, mouse
  • Akt2 protein, mouse
  • Autophagy-Related Protein-1 Homolog
  • Protein Serine-Threonine Kinases
  • Proto-Oncogene Proteins c-akt
  • TOR Serine-Threonine Kinases
  • Ulk1 protein, mouse
  • Calcium