Ultrafast synaptic endocytosis cycles to the center stage

Lujia Zhou; Joseph McInnes; Patrik Verstreken

doi:10.1016/j.devcel.2013.12.017

Ultrafast synaptic endocytosis cycles to the center stage

Dev Cell. 2014 Jan 13;28(1):5-6. doi: 10.1016/j.devcel.2013.12.017.

Authors

Lujia Zhou¹, Joseph McInnes¹, Patrik Verstreken²

Affiliations

¹ VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium.
² VIB Center for the Biology of Disease, 3000 Leuven, Belgium; Department of Human Genetics, KU Leuven, 3000 Leuven, Belgium. Electronic address: patrik.verstreken@cme.vib-kuleuven.be.

PMID: 24434135
DOI: 10.1016/j.devcel.2013.12.017

Abstract

Upon synaptic vesicle fusion, the neuronal membrane surface expands. Clathrin-mediated endocytosis compensates for this expansion but is a slow process. Recent studies in eLife and Nature identify an ultrafast mode of endocytosis, occurring in the space between active and periactive zones, that compensates for membrane addition during vesicle fusion.

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MeSH terms

Animals
Endocytosis*
Hippocampus / cytology*
Synapses / metabolism*