Abstract
Taxol does not affect axonal transport in cultured neurites. Preincubation of this drug inhibits the effects of colchicine on axonal transport and morphology in cultured neurites. A reduction of the free tubulin density by preincubated taxol might prevent the disruption of microtubules by colchicine.
MeSH terms
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Alkaloids / pharmacology*
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Animals
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Axonal Transport / drug effects*
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Axons / drug effects
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Axons / metabolism*
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Cells, Cultured
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Colchicine / pharmacology*
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Ganglia, Spinal / cytology
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Ganglia, Spinal / drug effects
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Ganglia, Spinal / metabolism*
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Mice
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Mice, Inbred C57BL
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Microtubules / drug effects
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Microtubules / physiology
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Paclitaxel
Substances
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Alkaloids
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Paclitaxel
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Colchicine