Taxol counteracts colchicine blockade of axonal transport in neurites of cultured dorsal root ganglion cells

Brain Res. 1987 Sep 8;420(1):144-6. doi: 10.1016/0006-8993(87)90249-6.

Abstract

Taxol does not affect axonal transport in cultured neurites. Preincubation of this drug inhibits the effects of colchicine on axonal transport and morphology in cultured neurites. A reduction of the free tubulin density by preincubated taxol might prevent the disruption of microtubules by colchicine.

MeSH terms

  • Alkaloids / pharmacology*
  • Animals
  • Axonal Transport / drug effects*
  • Axons / drug effects
  • Axons / metabolism*
  • Cells, Cultured
  • Colchicine / pharmacology*
  • Ganglia, Spinal / cytology
  • Ganglia, Spinal / drug effects
  • Ganglia, Spinal / metabolism*
  • Mice
  • Mice, Inbred C57BL
  • Microtubules / drug effects
  • Microtubules / physiology
  • Paclitaxel

Substances

  • Alkaloids
  • Paclitaxel
  • Colchicine