HOXB13, RFX6 and prostate cancer risk

Ian G Mills

doi:10.1038/ng.2881

HOXB13, RFX6 and prostate cancer risk

Nat Genet. 2014 Feb;46(2):94-5. doi: 10.1038/ng.2881.

Author

Ian G Mills¹

Affiliation

¹ Prostate Cancer Research Group, Centre for Molecular Medicine Norway (NCMM), University of Oslo and Oslo University Hospitals, Oslo, Norway, and with the Departments of Cancer Prevention and Urology, Institute of Cancer Research and Oslo University Hospitals, Oslo, Norway.

PMID: 24473320
DOI: 10.1038/ng.2881

Abstract

A new study shows that HOXB13 is preferentially recruited to the risk allele of a prostate cancer-associated SNP, enhancing the expression of RFX6, a driver of prostate cancer cell migration and predictor of disease progression. The work illustrates how a single risk locus contributes both to prostate cancer incidence and, through functional follow-up, to disease progression.

Publication types

Comment

MeSH terms

Chromatin / metabolism*
Chromosomes, Human, Pair 6 / genetics*
DNA-Binding Proteins / genetics*
Gene Expression Regulation, Neoplastic / genetics*
Genetic Predisposition to Disease / genetics*
Homeodomain Proteins / metabolism*
Humans
Male
Prostatic Neoplasms / genetics*
Regulatory Factor X Transcription Factors
Transcription Factors / genetics*

Substances

Chromatin
DNA-Binding Proteins
HOXB13 protein, human
Homeodomain Proteins
Regulatory Factor X Transcription Factors
Rfx6 protein, human
Transcription Factors