Human chorionic gonadotropin, angiogenic factors, and preeclampsia risk: a nested case-control study

Acta Obstet Gynecol Scand. 2014 May;93(5):454-62. doi: 10.1111/aogs.12363.

Abstract

Objective: To study whether human chorionic gonadotropin concentrations during pregnancy or combinations of human chorionic gonadotropin and other angiogenic factors, soluble fms-like tyrosine kinase 1 and placental growth factor (PlGF), are associated with preeclampsia risk.

Design: Nested case-control study.

Setting: Population cohort of pregnant women.

Sample: A total of 121 cases of preterm (<37 weeks) and 158 cases of term preeclampsia (≥37 weeks of gestation) and 356 women without preeclampsia (controls).

Methods: Women with preeclampsia were identified by linkage to the Medical Birth Registry of Norway. Concentrations of human chorionic gonadotropin, soluble fms-like tyrosine kinase 1 and PlGF were measured in maternal serum samples collected in each trimester of pregnancy.

Main outcome measures: Odds ratios of preterm and term preeclampsia.

Results: High human chorionic gonadotropin concentrations (highest quartile) in the first trimester were associated with reduced risk for preterm preeclampsia (OR 0.3, 95% CI 0.1-0.9), compared with low human chorionic gonadotropin (lowest quartile), whereas high human chorionic gonadotropin concentrations in the second trimester were associated with increased risk for preterm preeclampsia (OR 4.0, 95% CI 1.8-8.9). High human chorionic gonadotropin concentrations in the third trimester were associated with increased risk for term preeclampsia (OR 4.8, 95% CI 1.8-13.3). Concentrations of human chorionic gonadotropin above the median value combined with PlGF below the median in the second trimester were associated with very high risk for preterm preeclampsia (OR 36.9, 95% CI 8.2-165.8).

Conclusions: The results suggest an important role of human chorionic gonadotropin in the pathophysiological processes that lead to preeclampsia. The combined association of human chorionic gonadotropin and PlGF indicates a possible synergism between underlying biological pathways.

Keywords: Human chorionic gonadotropin; angiogenesis; hypertension in pregnancy; placental growth factor; preeclampsia; soluble fms-like tyrosine kinase 1.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Biomarkers / blood
  • Case-Control Studies
  • Chorionic Gonadotropin / blood*
  • Female
  • Gestational Age
  • Humans
  • Norway / epidemiology
  • Placenta Growth Factor
  • Pre-Eclampsia / blood*
  • Pre-Eclampsia / epidemiology*
  • Pregnancy
  • Pregnancy Proteins / blood*
  • Pregnancy Trimesters*
  • Premature Birth / blood
  • Premature Birth / epidemiology
  • Risk Factors
  • Vascular Endothelial Growth Factor Receptor-1 / blood*
  • Young Adult

Substances

  • Biomarkers
  • Chorionic Gonadotropin
  • PGF protein, human
  • Pregnancy Proteins
  • Placenta Growth Factor
  • FLT1 protein, human
  • Vascular Endothelial Growth Factor Receptor-1