Urinary intestinal fatty acid binding protein predicts necrotizing enterocolitis

J Pediatr. 2014 Jun;164(6):1486-8. doi: 10.1016/j.jpeds.2014.01.057. Epub 2014 Mar 15.

Abstract

Necrotizing enterocolitis, characterized by sudden onset and rapid progression, remains the most significant gastrointestinal disorder among premature infants. In seeking a predictive biomarker, we found intestinal fatty acid binding protein, an indicator of enterocyte damage, was substantially increased within three and seven days before the diagnosis of necrotizing enterocolitis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomarkers / urine
  • Birth Weight
  • Cohort Studies
  • Disease Progression
  • Enterocolitis, Necrotizing / physiopathology*
  • Enterocolitis, Necrotizing / urine*
  • Fatty Acid-Binding Proteins / urine*
  • Female
  • Gestational Age
  • Hospitals, Pediatric
  • Humans
  • Infant, Newborn
  • Infant, Premature*
  • Male
  • Odds Ratio
  • Predictive Value of Tests
  • Prognosis
  • ROC Curve
  • Retrospective Studies
  • Risk Assessment
  • Severity of Illness Index
  • Statistics, Nonparametric

Substances

  • Biomarkers
  • Fatty Acid-Binding Proteins