Association of the IL-10 receptor A536G (S138G) loss-of-function variant with recurrent miscarriage

Am J Reprod Immunol. 2014 Jul;72(1):1-4. doi: 10.1111/aji.12227. Epub 2014 Apr 1.

Abstract

Problem: We investigated the association of interleukin-10 receptor (IL10R1) loss-of-function variant A536G/S138G with recurrent pregnancy loss (RPL).

Method of study: Study subjects comprised 300 women with ≥3 miscarriages, and 350 control women.

Results: Significantly higher 536G-allele frequency was seen in RPL cases, thus assigning pathogenic role for this allele. Significant difference in A536G/S138G genotypes distribution was seen between RPL cases and controls, evidenced by enrichment of 536A/G and 536G/G genotypes in RPL cases. Setting A/A genotype as reference (OR = 1.00), increased RPL risk was seen with 536A/G, and more in 536G/G carriers, thereby establishing dose-dependency.

Conclusion: IL10R1 loss-of-function A536/S138G polymorphism may contribute to RPL pathogenesis.

Keywords: IL-10 receptor; polymorphisms; pregnancy; recurrent miscarriage.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Abortion, Habitual / genetics*
  • Adult
  • Case-Control Studies
  • Female
  • Genetic Predisposition to Disease / genetics*
  • Genotype
  • Humans
  • Multiplex Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide
  • Pregnancy
  • Receptors, Interleukin-10 / genetics*
  • Retrospective Studies

Substances

  • Receptors, Interleukin-10