Increasing serum levels of vitamin A, D and E are associated with alterations of different inflammation markers in patients with multiple sclerosis

J Neuroimmunol. 2014 Jun 15;271(1-2):60-5. doi: 10.1016/j.jneuroim.2014.03.014. Epub 2014 Mar 24.

Abstract

To explore the relationships between vitamin A, D and E and inflammation in relapsing remitting multiple sclerosis, we assessed their associations with 11 inflammation markers in 9 serial serum samples from 85 patients, before and during interferon-β1a treatment. A negative association was found between vitamin A and pentraxin 3 independent of interferon-β1a use, whereas positive associations between vitamin D and interleukin-1 receptor antagonist and secreted frizzled-related protein 3 were seen before, and between vitamin E and chemokine (C-X-C motif) ligand 16 during interferon-β1a treatment. These findings suggest associations with diverse inflammatory pathways, which may be differentially influenced by interferon-β1a treatment.

Keywords: Inflammation; Multiple sclerosis; Vitamin A; Vitamin D; Vitamin E.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Biomarkers / blood
  • C-Reactive Protein / metabolism
  • Cytokines / blood*
  • Docosahexaenoic Acids / therapeutic use
  • Double-Blind Method
  • Eicosapentaenoic Acid / therapeutic use
  • Female
  • Follow-Up Studies
  • Humans
  • Immunologic Factors / therapeutic use
  • Interferon-beta / therapeutic use
  • Male
  • Middle Aged
  • Multiple Sclerosis / blood*
  • Multiple Sclerosis / drug therapy
  • Multiple Sclerosis / immunology*
  • Serum Amyloid P-Component / metabolism
  • Time Factors
  • Vitamin A / blood
  • Vitamin D / blood
  • Vitamin E / blood
  • Vitamins / blood*

Substances

  • Biomarkers
  • Cytokines
  • Immunologic Factors
  • Serum Amyloid P-Component
  • Vitamins
  • Vitamin A
  • Vitamin D
  • Vitamin E
  • PTX3 protein
  • Docosahexaenoic Acids
  • Interferon-beta
  • C-Reactive Protein
  • Eicosapentaenoic Acid