Genetic variations of MMP9 gene and intracerebral hemorrhage susceptibility: a case-control study in Chinese Han population

Jie Yang; Bo Wu; Sen Lin; Junshan Zhou; Yingbin Li; Wei Dong; Hisatomi Arima; Chanfei Zhang; Yukai Liu; Ming Liu; Chengdu stroke registry and Nanjing First Hospital stroke registry investigators

doi:10.1016/j.jns.2014.03.049

Genetic variations of MMP9 gene and intracerebral hemorrhage susceptibility: a case-control study in Chinese Han population

J Neurol Sci. 2014 Jun 15;341(1-2):55-7. doi: 10.1016/j.jns.2014.03.049. Epub 2014 Apr 2.

Affiliations

¹ Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China; Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
² Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China.
³ Department of Neurology, Nanjing First Hospital, Nanjing Medical University, Nanjing 210006, China.
⁴ Department of Neurosurgery, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, China.
⁵ The George Institute for Global Health, Royal Prince Alfred Hospital and University of Sydney, Sydney, NSW 2050, Australia.
⁶ Department of Neurology, West China Hospital, Sichuan University, Chengdu 610041, China. Electronic address: wyplmh@hotmail.com.

PMID: 24774749
DOI: 10.1016/j.jns.2014.03.049

Abstract

Objective: To investigate the association between genetic variations of matrix metalloproteinase 9 (MMP9) gene and intracerebral hemorrhage (ICH) susceptibility in Chinese Han population.

Methods: The clinical data and peripheral blood samples from the patients with ICH and hypertension, and controlled subjects with hypertension only, were collected. MassARRAY Analyzer was used to genotype the tagger single nucleotide polymorphism (SNP) of MMP9 gene. Haploview4.2 and Unphased3.1.7 were employed to construct haplotypes and to analyze the association between genetic variations (alleles, genotypes and haplotypes) of MMP9 gene and ICH susceptibility.

Results: 181 patients with ICH and hypertension, and 197 patients with hypertension only, were recruited between Sep 2009 and Oct 2010. Patients in the ICH group were younger (61.80 ± 13.27 vs. 72.44 ± 12.71 years, p<0.05). Other conventional risk factors between the ICH and control groups were similar. There were 6 Tagger SNPs and 4 haplotypes of MMP9 gene in our sample population. Our logistical regression analysis showed that there were no significant associations between genetic variations of the MPP9 gene and ICH susceptibility (all p>0.05).

Conclusions: The genetic variations of MMP9 gene were not significantly associated with ICH susceptibility in the Chinese Han population.

Keywords: Etiology; Genotype; Haplotype; Intracerebral hemorrhage; Matrix metalloproteinase 9; Single nucleotide polymorphism.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Aged
Aged, 80 and over
Asian People / ethnology
Asian People / genetics
Case-Control Studies
Cerebral Hemorrhage / complications
Cerebral Hemorrhage / genetics*
Computational Biology
Female
Gene Frequency
Genetic Predisposition to Disease / genetics*
Genetic Testing
Genotype
Humans
Hypertension / complications
Logistic Models
Male
Matrix Metalloproteinase 9 / genetics*
Middle Aged
Polymorphism, Single Nucleotide / genetics*
Statistics, Nonparametric

Substances

Matrix Metalloproteinase 9