Abstract
A query and response regarding a patient who was taking high-dose tramadol and duloxetine is presented. The patient developed serotonin syndrome. Risks for this clinically important drug interaction and management of the syndrome are discussed.
Keywords:
cyproheptadine; drug; duloxetine; interaction; pain; serotonin syndrome; tramadol.
MeSH terms
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Analgesics / adverse effects
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Analgesics / therapeutic use
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Analgesics, Opioid / administration & dosage
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Analgesics, Opioid / adverse effects
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Analgesics, Opioid / therapeutic use
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Chronic Pain / drug therapy*
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Dose-Response Relationship, Drug
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Drug Interactions
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Duloxetine Hydrochloride
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Female
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Humans
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Middle Aged
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Serotonin Syndrome / chemically induced*
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Thiophenes / adverse effects*
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Thiophenes / therapeutic use
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Tramadol / administration & dosage
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Tramadol / adverse effects*
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Tramadol / therapeutic use
Substances
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Analgesics
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Analgesics, Opioid
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Thiophenes
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Tramadol
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Duloxetine Hydrochloride