Invasive fungal infections in solid organ transplant recipients

Clin Microbiol Infect. 2014 Sep:20 Suppl 7:27-48. doi: 10.1111/1469-0691.12660.

Abstract

Solid organ transplant (SOT) recipients have a significant risk of invasive fungal diseases (IFD) caused mainly by Candida spp. and Aspergillus spp. Candida spp. is the most frequent agent of IFD in the transplant recipient. The absence of clinical trials and the epidemiological differences in IFD in different transplant programmes mean that there are no definitive recommendations for the diagnosis, treatment and prevention of IFD in SOT, so most of the evidence must be based on clinical experience.

Keywords: Drug interactions; Transplant infectious disease; invasive aspergillosis; invasive candidiasis; solid organ transplantation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Candidiasis, Invasive / diagnosis
  • Candidiasis, Invasive / epidemiology*
  • Candidiasis, Invasive / prevention & control
  • Candidiasis, Invasive / therapy
  • Humans
  • Immunocompromised Host
  • Immunosuppressive Agents / therapeutic use
  • Invasive Pulmonary Aspergillosis / diagnosis
  • Invasive Pulmonary Aspergillosis / epidemiology*
  • Invasive Pulmonary Aspergillosis / prevention & control
  • Invasive Pulmonary Aspergillosis / therapy
  • Opportunistic Infections / diagnosis
  • Opportunistic Infections / epidemiology*
  • Opportunistic Infections / prevention & control
  • Opportunistic Infections / therapy
  • Organ Transplantation*
  • Transplant Recipients*

Substances

  • Immunosuppressive Agents